The researchers devised a first-of-kind subclassification scheme for IVCD. IVCD was defined overall as QRS 101 to 120 ms irrespective of morphology, or as QRS > 120 ms not identifiable as BBB. LBBB and RBBB were identified according to standard definitions (QRS duration > 120 ms). The present study categorized QRS duration as narrow (≤ 100 ms) or prolonged (> 100 ms), with prolongation further classified into LBBB, right bundle branch block (RBBB) and intraventricular conduction delay (IVCD). The Cleveland Clinic Coordinating Center for Clinical Research ( C5Research) adjudicated all-cause and cardiovascular mortality as well as heart failure (HF) hospitalizations and ECG results. Patients enrolled underwent a baseline 12-lead ECG. PRECISION found in 2016 that celecoxib does not confer excess cardiovascular risk and is associated with fewer cardiovascular adverse events compared with both naproxen and ibuprofen in patients with rheumatoid arthritis or osteoarthritis. This post hoc analysis included 22,607 (94%) of the randomized, double-blind, multicenter PRECISION trial’s 24,081 patients. “Our analysis makes a strong case for recognizing any type of delayed LV conduction among well-recognized cardiovascular risk factors, and thus changing how we think about overall cardiovascular health.” New subclassification scheme for intraventricular conduction delay “We have long established that delayed left ventricular conduction in the form of left bundle branch block confers markedly increased risk for cardiovascular and overall mortality in patients,” says the study’s corresponding and senior author, Daniel Cantillon, MD, of Cleveland Clinic’s Section of Electrophysiology and Pacing.
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